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Peptides / Other / Fat Loss

5-Amino-1MQ

Selective Small-Molecule NNMT Inhibitor for Metabolic and Mitochondrial Research

5-Amino-1MQ

5-Amino-1MQ is a targeted small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) under investigation for its capacity to maximize cellular NAD+ levels and activate the AMPK pathway. Peer-reviewed research highlights its applications in metabolic dysfunction, adipose tissue modulation, and cellular aging models. In laboratory settings, high-purity reconstituted liquid formulations are studied to bypass first-pass hepatic metabolism and overcome poor oral bioavailability.

Typical dose
1.0 - 3.0 mg/day (subject-dependent in animal models)
Half-life
Approximately 4 - 6 hours (estimated in preclinical models)
Administration
Subcutaneous or Intramuscular Injection (sterile reconstituted solution)
Research status
Preclinical / research use only
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What is 5-Amino-1MQ?

5-Amino-1MQ is a synthetic small molecule designed to inhibit nicotinamide N-methyltransferase (NNMT), an enzyme implicated in fat storage and metabolic regulation. In research discussions, NNMT activity is emphasized in liver and adipose tissue models where higher expression is associated with increased fat accumulation and reduced metabolic efficiency

Mechanisms of Action

  • Inhibit NNMT activity, shifting metabolism away from fat storage and toward greater fat oxidation

  • Improve metabolic efficiency by supporting higher energy expenditure and reduced fat accumulation signals

  • Support mitochondrial function and cellular energy output in metabolically stressed models

  • Reduce oxidative stress related markers downstream of improved mitochondrial performance

Benefits

  • Fat loss driven by increased fat oxidation and improved metabolic efficiency

  • Improved metabolic health markers, including insulin sensitivity signals in some research contexts

  • Increased perceived energy output in models where mitochondrial function is a limiting factor

Dosing

Strength

Capsules

Injectable

Low

50-100mg/day

250mcg/day

Medium

100-150mg/day

500mcg/day

High

150-200mg/day

1mg/day

Capsule dosing is often split into 2 to 3 doses per day.

Safety Profile

Mild gastrointestinal discomfort has been reported in some cases

Stacking

Fat Loss Stack:

  • 5-Amino-1MQ

  • Retatrutide

  • L-Carnitine

  • AOD-9604

Mitochondrial Stack:

  • 5-Amino-1MQ

  • MOTS-C

  • Methylene Blue

  • NAD+

Cognitive Stack:

  • 5-Amino-1MQ

  • Semax

  • Selank

  • NAD+

Disclaimer: The information provided is intended solely for educational purposes and should not be considered a replacement for professional medical advice. All compounds referenced are not for human consumption.

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