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Peptides / Peptides / Cosmetic / Skin

Melanotan 2

Synthetic Melanocortin Receptor Agonist for Melanogenesis and Metabolic Research

Melanotan 2

Melanotan 2 is a synthetic cyclic analog of alpha-melanocyte-stimulating hormone designed to non-selectively agonize melanocortin receptors. In laboratory research, it is primarily investigated for its photoprotective, appetite-regulating, and erectile-inducive capabilities across diverse animal models.

Typical dose
100 mcg - 250 mcg (preclinical equivalent, model-dependent)
Half-life
Approximately 1 to 2 hours (modeled in vivo)
Administration
Subcutaneous injection (preferred) or intranasal
Research status
Preclinical / research use only
Calculate a dose

What Is Melanotan 2?

Melanotan 2 is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH) developed to increase melanin production, skin pigmentation, and UV response. It is commonly discussed as having broader effects than Melanotan I, with additional activity related to sexual function and appetite signaling.

Mechanisms of Action

  • Melanin stimulation through activation of melanocortin receptors, increasing melanin production to darken skin tone and enhance tanning response.

  • Libido enhancement through melanocortin receptor signaling in the brain, which can increase sexual arousal and libido.

  • Appetite regulation through modulation of hunger related signaling, which may reduce food intake in some contexts.

Benefits

  • Cosmetic tanning support, accelerating pigmentation in individuals who tend to tan poorly.

  • Sexual function support signals, with research discussions noting increased libido and arousal.

  • Skin health and UV response support through higher melanin levels, providing some melanin mediated UV buffering similar to Melanotan I.

Dosing

Phase

Dose

Low

50 mcg daily

Medium

100 mcg daily

High

200 mcg daily

Maintenance

100 mcg, 2 times weekly

Cycle framing commonly discussed: 4 to 6 weeks, followed by breaks between cycles to reduce side effect burden.

Safety Profile

Melanotan 2 is often described as generally well tolerated, but side effects are commonly discussed and can be dose dependent.

  • Flushing can occur, particularly soon after administration.

  • Nausea or mild GI discomfort may occur in sensitive individuals.

  • Dark spots or freckling changes are discussed, especially in areas with higher sun exposure.

  • Increased libido is common and may be undesirable depending on the individual.

  • Appetite changes can occur, including reduced food intake.

Because it has multi system effects, research discussions commonly emphasize starting low and monitoring response before increasing exposure.

Stacking

Beauty Stack

  • MT-2

  • GHK-Cu

  • Glutathione

  • HGH

  • or CJC-1295 (No DAC) + Ipamorelin

  • or Tesamorelin

  • or Tesamorelin + Ipamorelin

Disclaimer: The information provided is intended solely for educational purposes and should not be considered a replacement for professional medical advice. All compounds referenced are not for human consumption.

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