Peak Strength Bio
Research Use Only: For research use only. Not for human consumption. Content is educational and is not medical advice, diagnosis, or treatment.
Peptides / Peptides

MOTS-c

Synthetic Mitochondrial-Derived Peptide-C for Metabolic and Energetic Research

MOTS-c

MOTS-c is a 16-amino-acid peptide encoded by the mitochondrial genome that regulates systemic metabolic homeostasis, primarily through the activation of the AMPK pathway. Peer-reviewed preclinical research shows it supports cellular insulin sensitivity, mitochondrial dynamic optimization, and exhibits distinct exercise-mimetic qualities in laboratory models.

Typical dose
2.5 mg to 5.0 mg systemically administered 2 to 3 times weekly in comparative rodent studies.
Half-life
Approximately 2 to 4 hours in rodent plasma models (undergoing active clearing and cellular uptake).
Administration
Subcutaneous or intraperitoneal injection in experimental animal models.
Research status
Preclinical / Research use only
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What Is MOTS-C?

MOTS-C is a mitochondrial-derived peptide (MDP) encoded by mitochondrial DNA (mtDNA). It is studied for its role in regulating metabolism, energy production, and cellular adaptation to stress, with particular interest in how it influences mitochondrial function and metabolic health in longevity oriented research.

Mechanisms of Action

  • Energy metabolism regulation that supports glucose metabolism, fat oxidation, and cellular energy production by improving mitochondrial efficiency.

  • Fat loss and metabolic efficiency signaling that promotes lipolysis, increases energy expenditure, and supports body composition endpoints.

  • Insulin sensitivity and glucose regulation effects that may improve insulin responsiveness, enhance glucose uptake, and support blood sugar stability in metabolic health models.

Benefits

  • Metabolic health and weight management support signals, with fat loss oriented endpoints while preserving lean mass in some study contexts.

  • Anti-aging and longevity interest through mitochondrial protection and reduced oxidative damage signals linked to age related metabolic decline.

  • Increased energy and endurance related endpoints through improved cellular resilience and physical performance measures in active or athletic models.

Dosing

2.5-5mg 2-3 days per week

Safety Profile

MOTS-C is commonly described as well tolerated, with relatively few adverse effects reported.

  • Mild injection site discomfort such as redness or swelling can occur.

  • Transient fatigue during an adjustment period is sometimes noted as the system adapts to increased mitochondrial activity.

Stacking

Anti-aging synergy:

  • Crystagen

  • Epithalon

  • GHK-Cu (including blends like GLOW or KLOW)

  • Humanin

  • Methylene Blue

  • NAD+

  • SS-31

Mitochondrial / energy-support models:

  • SS-31

  • 5-Amino-1MQ

  • NAD+

  • Methylene Blue

Neuroprotective pathways:

  • Methylene Blue

  • Cerebroprotein Hydrolysate (Cerebrolysin)

  • NAD+,

  • Dihexa

  • SS-31

  • Semax

  • Selank, FGL

  • DNSP-11

  • Humanin

Disclaimer: The information provided is intended solely for educational purposes and should not be considered a replacement for professional medical advice. All compounds referenced are not for human consumption.

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