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Peptides / Peptides / Cognitive & Nootropic

Semax

Synthetic ACTH(4-7) Analog Optimized for Neuroprotection and Synaptic Development Research

Semax

Semax is a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH 4-7) researched for its prospective neuroprotective, cognitive-restorative, and neuroplastic properties. Modified variants, including N-Acetyl Semax, feature improved pharmacokinetic stability, making them primary candidates for analyzing neurotrophic activity and synaptic recovery in laboratory models.

Typical dose
100 mcg - 500 mcg per nasal spray/injection in rodent assays
Half-life
Approximately 1.5 to 2 hours (prolonged in acetylated variants)
Administration
Intranasal or Subcutaneous (in laboratory models)
Research status
Preclinical / Research Use Only
Calculate a dose

What Is Semax?

Semax is a synthetic peptide derived from adrenocorticotropic hormone (ACTH) fragments. Originally developed in Russia, it has been studied for neuroprotective, cognitive-enhancing, and stress-regulating properties, with research interest in mental performance, neurological recovery, and stress resilience.

Mechanisms of Action

  • Neuroprotection and BDNF stimulation, increasing brain-derived neurotrophic factor (BDNF) signaling to support neuronal growth, repair, and synaptic plasticity.

  • Cognitive enhancement through modulation of dopamine, serotonin, and acetylcholine systems, supporting memory, focus, and learning capacity.

  • Anti-stress and HPA axis regulation through effects on the hypothalamic-pituitary-adrenal (HPA) axis, which may reduce stress, anxiety, and mental fatigue signals.

Benefits

  • Cognitive enhancement signals including improved memory retention, mental clarity, and focus, often discussed in performance-demanding contexts.

  • Stress and fatigue reduction signals, supporting lower perceived mental and physical strain in high-demand environments.

  • Neurological recovery support signals in research frameworks involving stroke, traumatic brain injury (TBI), and neurodegenerative conditions, tied to broader brain resilience endpoints.

Dosing

Route

Dose

Intranasal spray

400 to 800 mcg daily, divided into 2 to 3 administrations

Subcutaneous injection

100 to 300 mcg daily, often preferred in the morning to reduce late-day overstimulation signals

Safety Profile

Semax is generally described as well tolerated with minimal side effects in research discussions.

  • Mild nasal irritation can occur with intranasal administration.

  • Headaches can occur, particularly at higher doses.

  • Mild overstimulation can occur, especially if taken later in the day.

Semax is commonly described as not having sedative effects or dependence risk, which is why it is often positioned as an alternative to traditional stimulants or anxiolytics in these discussions.

Stacking

Cognitive Stack

  • Semax

  • Selank

  • Dihexa

  • Methylene Blue

  • NAD+

Neuroprotection Stack

  • Semax

  • SS-31

  • MOTS-c

  • NAD+

  • Methylene Blue

  • Dihexa

Disclaimer: The information provided is intended solely for educational purposes and should not be considered a replacement for professional medical advice. All compounds referenced are not for human consumption.

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